Chronic cancer pain
Conditions
Interventions
Hydromorphone Extended Release Tablets Group:Hydromorphone Extended Release Tablets
Oxycodone Extended Release Tablets Group:Oxycodone Extended Release Tablets
Sponsors
The second affiliated hospital of Zhejiang University school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with malignant tumors through cell pathology or tissue pathology, and who are in stage III-IV and unable to undergo surgery or radiotherapy/chemotherapy; 2.Meets the diagnostic criteria for refractory cancer pain, which means that even after standardized use of existing analgesics, the pain is still difficult to control (NRS score >= 4 on the numerical scoring system); 3.Expected survival period>3 months; 4.Age range: 18-80 years old; 5.The patient signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1.There is severe liver and kidney dysfunction (such as transaminase exceeding the upper limit of normal by three times, creatinine clearance rate<30ml/min); 2.History of drug abuse or allergy to opioid drugs; 3.Combining severe mental illness or consciousness disorders, unable to accurately express the degree of pain; 4.Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity of adverse events;Change in pain intensity score (NRS) from baseline after 7 days of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in laboratory inspection indicators;Opioid related symptom score;Patient satisfaction rating;Number of painful outbursts.;Pain relief rate;Quality of life score; | — |
Countries
China
Contacts
Public ContactMin Yan
The second affiliated hospital of Zhejiang University school of medicine
Outcome results
None listed