esophageal cancer
Conditions
Interventions
Physiological saline control group (CON group):Intranasal atomization of normal saline
0.5 mg/kg Esketamine group (E1 group):Intervention Intranasal atomization of 0.5mg/kg esketamine + normal saline
1.0 mg/kg Esketamine group (E2 group):Intervention Intranasal atomization of 1.0mg/kg esketamine + normal saline
Sponsors
Anhui Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 60 and 80 years, any gender; 2. ASA class II-III; 3. BMI 18-30 kg/m^2; 4. Patient or family requests esophageal cancer thoracoabdominal laparoscopic surgery under general anesthesia; 5. Able to understand and voluntarily sign the informed consent form, and willing to comply with the requirements of the trial protocol.
Exclusion criteria
Exclusion criteria: 1. Individuals allergic or contraindicated to benzodiazepines, opioids, propofol, flumazenil, naloxone, ketamine, and other drugs or their components; 2. Patients with severe heart, lung, or kidney dysfunction, those with multiple chronic diseases who cannot tolerate surgical anesthesia, and patients with mental disorders; 3. Those with increased intracranial or intraocular pressure; 4. Individuals with a history of alcohol abuse, opioid allergy, or opioid abuse; 5. Severe nasal anatomical deformities; 6. Those with a history of mental illness or long-term use of antidepressants; 7. Patients with uncontrolled severe hypertension; 8. Other situations deemed unsuitable for enrollment by the investigator; 9. Patients with recent neurological diseases or surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ramsay sedation score at 24h postoperatively ;IL-6 level at 24h postoperatively ;VAS pain score at 6h postoperatively ;MMSE cognitive score at 24h postoperatively ; | — |
Countries
China
Contacts
Public ContactYang Yue
Anhui Provincial Cancer Hospital
Outcome results
None listed