Knee joint diseases
Conditions
Interventions
Ropivacaine group:Adductor canal block was performed using ropivacaine
Bupivacaine liposome group:Adductor duct block was performed using bupivacaine liposomes
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective unilateral knee arthroplasty; 2.Aged 18–90 years, regardless of gender; 3.BMI: 18–30 kg/m^2; 4.ASA classification of II–IV; 5.Able to comprehend and perform assessments such as the Visual Analogue Scale (VAS) and the Confusion Assessment Method (CAM) for delirium scoring; 6.Voluntarily sign the informed consent form and agree to comply with the requirements of the study protocol.
Exclusion criteria
Exclusion criteria: 1.Severe cardiac, pulmonary, hepatic, or renal dysfunction; 2.History of psychiatric disorders or long-term use of psychotropic medications (e.g., dementia, schizophrenia), chronic analgesic use, or history of alcohol abuse; 3.Preoperative Mini-Mental State Examination (MMSE) score < 21, indicating moderate to severe cognitive impairment; 4.History of any cerebrovascular accident within the past 3 months, such as stroke or transient ischemic attack; 5. Patients with severe infections; 6. Preoperative PaO2 < 60 mmHg or SpO2 < 92%; 7. Participation in another drug clinical trial within the past 30 days; 8. Allergy to the investigational drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| CAM Scale;Assessment of joint motor function;TNF-a;IL-1ß;IL-10; | — |
Countries
China
Contacts
Public ContactXu Min
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed