colorectal cancer
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Participants who fully understand the nature, purpose, and potential benefits of the study prior to enrollment, are able to comprehend the study procedures and requirements, agree to comply with the protocol, and voluntarily sign the informed consent form. 2. Patients scheduled to undergo elective laparoscopic colorectal surgery. 3. Age >= 18 years, with no restrictions on sex. 4. American Society of Anesthesiologists (ASA) physical status classification I–III.
Exclusion criteria
Exclusion criteria: 1. Patients with hepatic dysfunction of Child-Pugh class B or above, renal insufficiency stage 2 or above, or cardiac function class III or IV. 2. Patients with hyperalgesia, other sensory disorders, or any concomitant pain condition that may interfere with postoperative pain assessment. 3. History of myocardial infarction or unstable angina within the past 6 months, or severe cardiac arrhythmias (e.g., second-degree or higher atrioventricular block). 4. Known allergy or contraindication to bupivacaine or other amide-type local anesthetics. 5. Patients with contraindications to transversus abdominis plane (TAP) block. 6. Pregnant or breastfeeding women, and women who are pregnant, planning to become pregnant within 6 months, or unwilling/unable to use effective contraception during the study. 7. History of psychiatric disorders or central nervous system diseases, or hearing/visual impairments that preclude cooperation with pain assessment scales. 8. Patients with diabetic peripheral neuropathy. 9. Any other condition that, in the investigator’s judgment, makes the patient unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of episodes with NRS pain score =4 at rest or during movement within 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| PCIA sufentanil total press counts and total infused dose within 48h after surgery;Highest NRS score (rest and movement) at 24h, 48h, and 72h postoperatively;Incidence and severity of adverse events within 72h postoperatively;Time to first flatus;Total intraoperative opioid consumption (converted to morphine milligram equivalents);Proportion of patients requiring rescue analgesia and total rescue analgesic dosage within 72h; | — |
Countries
China
Contacts
Public ContactYunchang Mo
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed