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LncRNA regulates the methylation of the Beclin1 promoter region to promote autophagy to induce triphenoxamine resistance in breast cancer

LncRNA LINRIS/SAHHD/NMT3B regulates the methylation of the Beclin1 promoter region to promote autophagy to induce triphenoxamine resistance in breast cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500114871
Enrollment
Unknown
Registered
2025-12-18
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

How can breast cancer mediate triphenoxylamine resistance through autophagy?

Interventions

Experimental group:None
Control group:None

Sponsors

The First Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Signed an informed consent form; 2.The patient is a patient after radical treatment of breast cancer; 3.The patient participates in postoperative adjuvant chemotherapy; 4.No serious systemic diseases; 5.No other related treatment has been carried out, such as new adjuvant chemotherapy, etc.

Exclusion criteria

Exclusion criteria: 1.The patient refuses to sign the informed consent form; 2.The patient needs to change the postoperative adjuvant chemotherapy plan due to the condition; 3.The patient refuses postoperative adjuvant chemotherapy; 4.The termination of postoperative adjuvant chemotherapy for any reason; 5.The patient's condition changes and needs to add other treatment methods; 6.The patient requests to withdraw from the project; 7.The patient is accompanied by other serious systemic diseases after surgery.

Design outcomes

Primary

MeasureTime frame
Complete various indicators of immunInvestigating the Regulatory Mechanisms of Trastuzumab Resistance in LNCRNA LINRIS/LINRIS/SAHHD/NMT3B/Beclin1 via Autophagy Activationohistochemistry using the patient's tissue samples;

Countries

China

Contacts

Public ContactZhang Wei

The First Affiliated Hospital of Xi'an Jiaotong University

59004940@qq.com+86 29 8532 4926

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026