mood changes
Conditions
Interventions
Anxious individuals group:None
Healthy individuals group:None
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Scheduled to undergo painless gastroscopy with simple endoscopic procedures, such as clipping of single small polyps, HP testing, etc. 2. No gender limitation. 3. Aged between 18 and 65 years old (inclusive). 4. Body mass index (BMI) ranging from 18 kg/m² to 30 kg/m² (exclusive). 5. American Society of Anesthesiologists (ASA) physical status classification: Class I–II. 6. Normal liver and kidney functions. 7. Provide informed consent, voluntarily participate in the trial, and sign the informed consent form by the subjects themselves
Exclusion criteria
Exclusion criteria: 1. Requiring endoscopic diagnosis and treatment technologies with complex procedures or strong noxious stimulation, such as removal of upper gastrointestinal foreign bodies, esophageal stricture dilation, etc. 2. Having severe cardio-cerebrovascular diseases, stroke, diabetes mellitus, etc. 3. Being identified as having difficult airway management. 4. Having hepatic or renal insufficiency. 5. Having a history of other mental or neurological diseases (e.g., schizophrenia, mania, bipolar disorder, confusion, epilepsy, neuralgia, etc.), a history of taking corresponding medications for mental or neurological diseases (e.g., antidepressants, anxiolytics, anticonvulsants, antiepileptics, etc.), or having cognitive impairment. 6. Having allergies or contraindications to the study drugs. 7. Having speech or cognitive dysfunction. 8. Having active infection (defined as white blood cell count > 10×10?/L or body temperature > 38?). 9. Having a history of chronic alcoholism. 11. Being pregnant women. 12. Having participated in other clinical trials of drugs or medical devices within 3 months prior to the screening period. 13. Refusing to participate in this study. 14. Being deemed ineligible by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of euphoria;Postoperative emotional outcome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Risk of euphoria addiction;Degree and duration of euphoria;Fatigue condition;Short-term sleep in the 72h postoperative period;Perioperative adverse events;Changes in postoperative anxiety level;Subjects' dreaming;Subjects' satisfaction with the quality of anesthesia;Pain level; | — |
Countries
China
Contacts
Public ContactJu Gao
Northern Jiangsu People's Hospital Anesthesiology Department
Outcome results
None listed