osteoarthropathy
Conditions
Interventions
rifampicin combined with antibiotic treatment group:Rifampicin combined with antibiotic treatment
antibiotic treatment group:antibiotic treatment
Sponsors
The First Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1 Diagnosed as PJI according to the MSIS criteria 2 The pathogenic bacteria were identified as Staphylococcus through microbial culture and drug sensitivity tests were conducted 3 There are complete clinical data 4 Age under 80 years old, without serious complications or immunosuppressive status 5 The patient voluntarily participated in this study and was physically and mentally tolerant of the treatment process and various tests in this study. They have signed the informed consent form and passed the review of the ethics committees of all hospitals participating in this study
Exclusion criteria
Exclusion criteria: 1 Those with chronic inflammation in other parts of the body before the operation 2 Non-staphylococcal infection or mixed infection 3 The patient has other diseases that may affect the outcome, such as immune deficiency or liver and kidney dysfunction 4 Those with an expected lifespan of less than half a year 5 The researcher determined that the patient no longer met the criteria of this study due to compliance issues 6 People allergic to rifampicin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score;Keen Society Score;Harris Score;C-reactive protein (CRP);ESR;Procalcitonin (PCT);interleukin-6 (IL-6);D-dimer;Fibrinogen; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;Biochemical function;Coagulation function;Joint fluid examination;Recurrence rate of periprosthetic infection;Other complications; | — |
Countries
China
Contacts
Public ContactZhang Wenming
The First Affiliated Hospital of Fujian Medical University
Outcome results
None listed