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Efficacy of Peri-Implant Bone Regeneration Among Elderly Osteoporotic Patients

Efficacy of Peri-Implant Bone Regeneration Among Elderly Osteoporotic Patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500114839
Enrollment
Unknown
Registered
2025-12-18
Start date
2025-12-20
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentition defect

Interventions

Control Group:None

Sponsors

West China Hospital of Stomatology, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 50 years and older. 2. In need of delayed implant placement in a single tooth gap at posterior healing sites. 3. Conducted routine annual physical examinations or specialized endocrine assessments which involved DXA measurement of BMD at the spine, hip, or forearm with a T-score above -2.5 within one year prior to oral implant therapy. 4. Presence of intra-osseous buccal bone dehiscence with a defect width of 1-3 mm and a defect depth of less than 50% of the implant length after implant placement. 5. Participants who have signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Diagnosis of osteoporosis based on DXA measurement of BMD at the spine, hip, or forearm (a T-score at -2.5 or more below) within the past 12 months 2. History of treatment with antiresorptive agents like bisphosphonates and denosumab). 3. Affected by other systemic diseases related to bone metabolism (e.g., Cushing's syndrome, Addison'sdisease and rheumatoid arthritis). 4. Psychological or psychiatric disorders requiring medication and unable to receive oral implant therapy. 5. Presenting an acute endodontic/periodontal lesion in the neighbouring areas to the implant site. 6. History of chemotherapy within 5 years prior to oral implant therapy. 7. History of radiation in the head and neck region. 8. Present alcohol and/or drug abuse. 9. History of smoking (>10 cigarettes per day). 10. Bone grafting extends more than 1 mm beyond the contour of the alveolar bone on CT cross-sections.

Design outcomes

Primary

MeasureTime frame
Alveolar ridge width change;

Secondary

MeasureTime frame
Patient reported outcomes (VAS pain score);Postoperative complications;Marginal bone loss;Implant tissue health status;Implant survival rate;

Countries

China

Contacts

Public ContactYang Xingmei

West China Hospital of Stomatology, Sichuan University

65167950@qq.com+86 28 8550 3579

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026