acute type A aortic dissection surgery
Conditions
Interventions
HA380 group:None
Control group:None
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years; 2. Patients diagnosed with acute type A aortic dissection and undergoing total arch replacement surgery under cardiopulmonary bypass; 3. Have signed a written informed consent form. (For the control group, they have previously signed a biobank informed consent form, agreeing to donate their samples and data for all medical research; for the HA380 group, participation in the study is voluntary and they have signed the informed consent form for this study)
Exclusion criteria
Exclusion criteria: 1. Patients with chronic kidney disease before surgery (receiving renal replacement therapy or with an eGFR [estimated glomerular filtration rate] <15 mL/min/1.73 m²); 2. Patients with evident organ hypoperfusion before surgery; 3. Patients using ECMO or VAD before surgery; 4. Myocardial infarction before surgery; 5. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of CSA-AKI within 7 days after surgery;Degree of CSA-AKI within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative APACHE II Score;Postoperative SOFA Score;Serum cTnT levels ;NT-proBNP levels at 24, 48, and 72 hours postoperative;CK-MB at 24, 48, and 72 hours postoperative;Main postoperative complications;Time in the ICU;Time in the hospital;Ventilator support duration;All-cause mortality during hospitalization; | — |
Countries
China
Contacts
Public ContactXin Li
Zhongshan Hospital, Fudan University
Outcome results
None listed