Olanzapine-induced lipid metabolism disorders
Conditions
Interventions
Sponsors
Shandong mental health center
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.All participants (patients' family members) signed the informed consent form after approval was obtained from the hospital ethics committee. 2. A total of 60 patients with first-episode schizophrenia who met the DSM-V diagnostic criteria were enrolled, regardless of gender, aged 18–45 years, and all received systematic monotherapy with the antipsychotic drug olanzapine. 3.First-episode schizophrenia patients meeting DSM-V diagnostic criteria. 4.Positive and Negative Syndrome Scale (PANSS) score >= 60, and Clinical Global Impression of Severity (CGI-S) score >= 4. 5.Patients' blood lipids, body weight, blood pressure, and blood glucose are all within the normal range.
Exclusion criteria
Exclusion criteria: 1.History of substance dependence or psychotic symptoms caused by other mental disorders. 2.Patients with suicidal attempts, suicidal ideation, or suicidal behavior. 3.Major physical diseases such as cardiovascular diseases, liver or renal dysfunction. 4. History of alcohol abuse or substance abuse within the past year; 5.Pregnant or breastfeeding patients; 6.Major physical illnesses such as cardiovascular disease, hepatic or renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proprotein Convertase Subtilisin/Kexin Type 9;Triglycerides ;Total Cholesterol ;Low-Density Lipoprotein;High-Density Lipoprotein ; | — |
Countries
China
Contacts
Public ContactRanRan Li
Shandong mental health center
Outcome results
None listed