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The Role of the TyG Index in Predicting Early Cardiac Dysfunction in Type 2 Diabetes Patients with Preserved Ejection Fraction

The Role of the TyG Index in Predicting Early Cardiac Dysfunction in Type 2 Diabetes Patients with Preserved Ejection Fraction

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500114821
Enrollment
Unknown
Registered
2025-12-17
Start date
2025-01-10
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

LVGLS18:nothing

Sponsors

Shenzhen Hospital, Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Aged >=18 years; 2.Diagnosed with type 2 diabetes mellitus according to the diagnostic and classification criteria outlined in the "Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2020 Edition)"; 3.LVEF >=50%; 4.Voluntarily signed informed consent form.

Exclusion criteria

Exclusion criteria: 1.Recent onset of acute diabetic complications, gestational diabetes, pregnancy, breastfeeding women. 2.Acute coronary syndrome, congenital heart disease, atrial fibrillation, severe valvular heart disease. 3.Acute and chronic infectious diseases, cancer. 4.Deemed unsuitable for participation in this study based on the investigator's judgment.

Design outcomes

Primary

MeasureTime frame
Triglyceride-Glucose and Visceral Fat Area index(TyG-VFA);left ventricular global longitudinal strain(LVGLS);Fasting blood glucose;Homeostasis Model Assessment 2 of Insulin Resistance;Triglyceride-Glucose-Visceral/Subcutaneous Fat Area;

Secondary

MeasureTime frame
Age;Gender;Height;Weight;Diabetes duration;Fasting C-peptide;HbA1c;Creatinine;Homocysteine;Triglyceride;Low-density lipoprotein;High-density lipoprotein;Cholesterol;Insulin-like growth factor 1;Left Atrial Diameter;Left ventricular end-diastolic diameter;Interventricular Septum;Ejection fraction;Triglyceride-Glucose index;Estimated glomerular filtration rate;Body Mass Index;Triglyceride-Glucose-Body Mass Index;Visceral Fat Area;Subcutaneous Fat Area;

Countries

China

Contacts

Public ContactLingling Xu

Shenzhen Hospital, Southern Medical University

lucylingl@126.com+86 135 3883 8066

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026