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Analysis of the effect of oral care with 0.12% compound chlorhexidine gargle on the prevention of pulmona

Analysis of the effect of oral care with 0.12% compound chlorhexidine gargle on the prevention of pulmona

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114814
Enrollment
Unknown
Registered
2025-12-17
Start date
2025-02-06
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

In the comprehensive management system of cardiovascular diseases, surgical treatment is a crucial means to restore patients' cardiac function and improve their quality of life. The incidence of postoperative pulmonary complications has become one of the important factors affecting surgical outcomes and patient prognosis, with the incidence rate ranging from 10% to 59%. Among these complications,

Interventions

test group:Postoperatively, patients were given oral care with 0.12% compound chlorhexidine rinse twice a day (after breakfast and before bed).
control subjects:After the patients surgery, oral care measures were carried out using cool white water twice a day (after breakfast and before bedtime).

Sponsors

Yuebei People’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. patients aged >= 18 years who underwent cardiac surgery in cardiovascular surgery and did not have lung infection before surgery; 2. those who were willing to accept and participate in this study and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. those who could not or refused to use 0.12% compound chlorhexidine gargle for oral care due to personal factors; 2. preoperative complications such as pleural effusion, pulmonary atelectasis, and pulmonary infection. (Diagnostic criteria for pulmonary complications [16]: a. Lung infection: elevated WBC (>=10 × 10^9 / L) or fever (body temperature >=38 ° C, and the temperature continues to rise for more than 24 h), chest X-ray shows signs of infection such as lamellar, lobar, and alveolar high-density infiltrative lesions, etc.); b. Lung atelectasis: prolonged coughing, tachypnea (respiratory rate of more than 25 breaths per minute), hemoptysis, and weight loss, which can be seen by imaging or laboratory tests, and is associated with a high risk for lung infection.c. Pulmonary oedema: coughing a large amount of white syrupy sputum or pink foamy sputum, symmetrical butterfly-like changes in both lungs, mainly in the central region of the lungs). 3.Pre-operative use of antibiotics; (iv) Patients with heart-lung transplantation; 4. Patients with heart-lung transplantation; 5. Patients who smoke (Smokers judgement criteria: smoking more than one cigarette per day and continuing to smoke for six months or more).

Design outcomes

Primary

MeasureTime frame
Incidence of pulmonary infections;

Secondary

MeasureTime frame
Oral Hygiene Status;Oral pH Value;The Severity of Pulmonary Infection;

Countries

China

Contacts

Public ContactXueling Xiao

Yuebei People’s Hospital

285293089@qq.com+86 751 6913274

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026