Kidney Cancer
Conditions
Interventions
case series:No
Sponsors
Renji Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: I. Early Diagnosis Cohort for Lung Metastasis 1. Patients with a history of renal cell carcinoma diagnosed through clinical medical history, imaging (CT, PET-CT, etc.), or pathology; patients with renal cell carcinoma history concurrent with pulmonary nodules; patients with renal cell carcinoma lung metastasis; patients with benign pulmonary nodules; patients with lung cancer; patients with lung metastasis from other malignant tumors. 2. Accessible initial clinical data and imaging studies. 3. Obtain patient informed consent. II. Prognosis and Efficacy Prediction Cohort 1. Patients with definitively diagnosed unresectable tumors or advanced tumors with >=1 radiologically confirmed metastatic lesion. (Note: The advanced clear cell renal cell carcinoma efficacy assessment cohort exclusively includes advanced renal cell carcinoma patients; the advanced pan-cancer efficacy validation cohort includes, but is not limited to, patients with metastatic renal cell carcinoma, hepatocellular carcinoma, lung cancer, endometrial carcinoma, and other advanced cancers). 2. Receiving systemic combination therapy with anti-vascular endothelial growth factor (anti-VEGF) or vascular endothelial growth factor receptor (VEGFR) targeted agents, or in combination with immune checkpoint inhibitors; 3. Possessing relatively complete clinical, imaging, and pathological data, including accessible pre-treatment imaging or laboratory records, or pre-treatment/post-treatment paraffin-embedded tissue samples/hematoxylin and eosin (HE)-stained tissue sections. 4. Having complete follow-up information; 5. Obtaining patient informed consent.
Exclusion criteria
Exclusion criteria: 1. Inability to obtain a definitive diagnosis; 2. Irregular follow-up imaging data; 3. Cases deemed ineligible by the investigator due to other factors; 4. Cases meeting all inclusion criteria and none of the exclusion criteria shall be selected as subjects for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Are pulmonary nodules in renal cancer patients indicative of lung metastasis?;Systemic therapy eesponse in renal cell carcinoma patients;ROC curve;AUC; | — |
Countries
China
Contacts
Public ContactZhai Wei
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed