Laryngeal Squamous Cell Carcinoma
Conditions
Interventions
Index test:Detection of Biomarkers in Urinary Exosomes Using Metabolomics and Proteomics
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Newly diagnosed with laryngeal squamous cell carcinoma and having received no prior treatment; 2.No second primary tumor; 3.No history of diabetes, hypertension, cardiovascular and cerebrovascular diseases, or immune system diseases; 4.Without infectious diseases such as hepatitis, syphilis, or HIV; 5.No recent history of acute infections (such as urinary tract infections) or significant chronic infections; 6.No history of surgery within the past 12 months.
Exclusion criteria
Exclusion criteria: 1.Combined with other malignant tumors; 2.History of radiotherapy or chemotherapy; 3.Severe hepatorenal dysfunction; 4.History of blood transfusion or blood product use prior to sample collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary Exosomal Metabolite Expression Profile;Urinary Exosomal Protein Expression Profile; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse Events;Biological Functions and Pathways of Differentially Expressed Proteins;Protein-Protein Interaction (PPI) Network of Differentially Expressed Proteins;Correlation of Candidate Metabolites with TNM Stage and Pathological Grade;Correlation of Candidate Proteins with TNM Stage and Pathological Grade; | — |
Countries
China
Contacts
Public ContactHu Weiming
Zhejiang Provincial People's Hospital
Outcome results
None listed