myocarditis
Conditions
Interventions
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosed with myocarditis at this center during the study period; 2. Having available baseline data (demographics, symptoms/signs, laboratory tests, imaging/EMB [if applicable], and treatment records); 3. Having at least one source of trackable outcome information (hospital records, readmissions, outpatient follow-ups, telephone follow-ups, death registries, etc.).
Exclusion criteria
Exclusion criteria: 1. Having alternative diagnoses that can fully explain myocardial injury (such as acute coronary syndrome with significant coronary stenosis, stress-induced cardiomyopathy, peripartum cardiomyopathy, previously diagnosed dilated/hypertrophic/restrictive cardiomyopathy, etc.); 2. Having a dominant phenotype of structural heart disease (moderate to severe valvular heart disease, complex congenital heart disease, etc.); 3. Having missing key baseline/outcome data that prevent the completion of the primary analysis. 4. Multiple admissions: Only the first admission is retained for each patient (subsequent admissions are considered as follow-up events).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause death or cardiac transplantation (whichever occurs first); | — |
Secondary
| Measure | Time frame |
|---|---|
| In-hospital and 30/90-day outcomes: in-hospital death, use of VA-ECMO/IABP/Impella, AKI, severe arrhythmias, pacemaker/ICD implantation.;Mid-to-long-term outcomes: rehospitalization for heart failure, recurrence of non-fatal ventricular arrhythmias, new-onset/recurrent atrial fibrillation, and recurrent myocarditis.;Laboratory and biomarkers: Cardiac troponin (cTnI/T), NT-proBNP/BNP, CRP, renal function (creatinine/eGFR), and electrolytes.;Imaging/Function: Changes in LVEF, LVEDD, left atrial volume index, E/e', CMR LGE extent/distribution, native T1/T2, and ECV.;Functional recovery and recurrence: The proportion and time of LVEF recovery to >=50% or an absolute increase of >=10% from baseline; recurrent myocarditis; | — |
Countries
China
Contacts
Public ContactRong Jiang
Shanghai General Hospital
Outcome results
None listed