Acute DeBakey Type I Aortic Dissection
Conditions
Interventions
hemi-arch group:Patients underwent hemi-arch replacement.
total-arch group:Patients underwent total-arch replacement.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with acute DeBakey type I aortic dissection. 2. Patients between the ages of 18 and 70 years. 3. Patients in whom both hemiarch and total arch replacement are deemed anatomically and physiologically suitable by the operating surgeon. 4. Patients capable of understanding the trial requirements and treatment procedures, and providing written informed consent.
Exclusion criteria
Exclusion criteria: 1. Hemodynamically unstable patients requiring CPR or ECMO support. 2. History of previous open-heart surgery or thoracic endovascular aortic repair. 3. Patients with an aortic arch diameter >5.5 cm necessitating concomitant arch replacement. 4. Presence of an intimal tear or aneurysm in the aortic arch. 5. Evidence of any malperfusion (e.g., neurological deficit, mesenteric ischemia, limb ischemia). 6. Severe hepatic insufficiency (Child-Pugh class B or C, or MELD score =15). 7. Chronic renal failure (baseline eGFR <50 mL/min/1.73m²) or dialysis dependence. 8. Metastatic solid tumor or hematologic malignancy. 9. Pregnancy or lactation. 10. Diagnosis of connective tissue disease. 11. Patients deemed likely to be lost to follow-up or unwilling to comply with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality;Reintervention rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the ratio of true lumen to total aortic area; | — |
Countries
China
Contacts
Public ContactChaoyi Qin
Department of Cardiovascular Surgery and Cardiovascular Surgery Research Laboratory, West China Hospital, Sichuan University
Outcome results
None listed