Cardiac Surgery-Associated Acute Kidney Injury
Conditions
Interventions
Active Group:1. Stimulation method: The left auricular concha is selected as the stimulation site. The left external auditory canal and conchal area are first cleaned with an alcohol swab, after which
current intensity 1–3 mA (adjusted according to patient tolerance)
duty cycle 100%.
3. Stimulation protocol: After the initiation of cardiopulmonary bypass, taVNS is applied for 30 minutes. On the day of surgery, an additional 20-minute stimulation is administered af
Sham Group:1. Sham stimulation method: The left auricular concha is selected as the stimulation site. The left external auditory canal and conchal area are first cleaned with an alcohol swab, after wh
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Scheduled to undergo elective cardiac surgery with cardiopulmonary bypass, with an expected cardiopulmonary bypass duration of more than 90 minutes; 3.Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients undergoing emergency surgery; 2. Chronic kidney disease (CKD) stage 4 or higher (eGFR 10 mg/day prednisone or equivalent); 5.Severe ear disease (e.g., auricular infection, auricular malformation) preventing proper electrode placement or posing a risk of local injury; 6. Severe neurological disease or documented vagus nerve injury; 7.Severe gastrointestinal disease; 8.Pre-existing asthma before surgery; 9. Pre-existing epilepsy before surgery; 10.Presence of an implanted cardiac pacemaker, cochlear implant, or other electronic implantable device; 11.Preoperative severe cardiac arrhythmias, such as high-grade atrioventricular block or sick sinus syndrome; 12.Infective endocarditis; 13.Refusal or inability to provide written informed consent; 14. Deemed unsuitable for inclusion in this study at the discretion of the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of CSA-AKI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Urine output;Serum creatinine level;Incidence of postoperative kidney replacement therapy (KRT);Levels of inflammatory cytokines (IL-2IL-6 IL-8IL-10IFN-?TNFCRP);B-type natriuretic peptide;CTnI;Lac;Sequential Organ Failure Assessment;Acute physiology and chronic Health Evaluation II;Duration of postoperative invasive mechanical ventilation;ICU length of stay;Hospital length of stay;All-cause mortality within 30 days after surgery;All-cause mortality within 90 days after surgery;Standard Deviation of Normal-to-Normal RR intervals;24h Averaged Root Mean Square of Successive Differences;NT-proBNP; | — |
Countries
China
Contacts
Public ContactZhang Chengxin
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed