Gynecological diseases
Conditions
Interventions
Ciprofol group:Ciprofol administered intravenously at an initial dose of 0.36 mg/kg, adjusted sequentially using the up-and-down method with a step of 0.04 mg/kg, combined with a fixed dose of alfenta
Propofol:Patients receive intravenous propofol at an initial dose of 1.5 mg/kg, with a dose adjustment step of 0.5 mg/kg, combined with a fixed dose of alfentanil 15 µg/kg. Laryngeal mask airway inser
Sponsors
Tai'an Central Hospital (Qingdao University Affiliated Tai'an Central Hospital, Taishan Medical Care Center)
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Female patients aged 18–65 years; 2.American Society of Anesthesiologists (ASA) physical status I–II; 3.Patients scheduled for elective gynecological laparoscopic surgery under general anesthesia, with planned laryngeal mask airway ventilation; 4.Body mass index (BMI) between 18.5 and 30 kg/m^2; 5.Airway assessment of Mallampati class I–II, with no anticipated difficult airway; 6.Patients who provide informed consent and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Individuals with known allergies to ciprofol , alfentanil, propofol, or any components of their formulations; 2.Patients with severe cardiac, pulmonary, hepatic, or renal dysfunction, or serious endocrine or metabolic disorders; 3.Patients with severe anemia (Hb 35 kg/m^2); 6.Patients on long-term use of sedative-hypnotics, opioid analgesics, or psychotropic medications; 7.Other conditions deemed by the investigators as unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Laryngeal mask airway insertion response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), peripheral oxygen saturation (SpO?), and bispectral index (BIS).; | — |
Countries
China
Contacts
Public ContactTianran Zhang
Tai'an Central Hospital (Qingdao University Affiliated Tai'an Central Hospital, Taishan Medical Care Center)
Outcome results
None listed