Sepsis-induced Coagulopathy, SIC
Conditions
Sponsors
The Second Affiliated Hospital of Xi’an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Meeting the diagnostic criteria for "Sepsis and Septic Shock as defined by the Third International Consensus Definitions" within 6 hours of ICU admission; 3.Meeting the diagnostic criteria for Sepsis-Induced Coagulopathy (SIC) as defined by the ISTH within 6 hours of ICU admission; 4.TAT/PIC level > 5 within 6 hours of ICU admission; 5.Expected ICU length of stay > 72 hours; 6.Informed consent obtained from the patient or legally authorized representative.
Exclusion criteria
Exclusion criteria: 1.Patients with an ISTH overt DIC score >= 5 (meeting the diagnostic criteria for overt DIC) within 24 hours after SIC diagnosis and prior to the initiation of anticoagulant therapy must be immediately excluded from the study; 2.History of major surgery or severe trauma within 72 hours prior to ICU admission; presence of severe bleeding tendency, intracranial hemorrhage, or uncontrolled active major bleeding. 3.Comorbidities with irreversible end-stage diseases (e.g., advanced malignancy, end-stage liver disease); pregnancy or lactation; long-term use of high-dose immunosuppressive agents; severe psychiatric disorders; history of alcohol abuse. 4.Use of anticoagulant medications within 48 hours prior to SIC diagnosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ICU mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Major bleeding;CRP Change;Disseminated Intravascular Coagulation (DIC) Onset;TAT/PIC Change;28-day mortality; | — |
Countries
China
Contacts
Public ContactJiamei Li
The Second Affiliated Hospital of Xi’an Jiaotong University
Outcome results
None listed