atelectasis,lung-protective ventilation
Conditions
Interventions
Experimental group:The initial time interval of PARM was 0.5 hours/time, and the different interval of PARM was assigned by random partial coin sequential method.If the previous patient did not respon
If lung opening is effective, there is an 11% chance that the next patient will have an 10-minute expansion interval and an 89% chance that the time interval will remain unchanged.
Sponsors
The Sixth Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Elective laparoscopic head-down major abdominal surgery (2h=16, see Appendix 1) 3. SpO2>=94% when inhaling air 4. Age 65-80
Exclusion criteria
Exclusion criteria: 1. History of pneumonia or >= 1 hour of mechanical ventilation within 1 month prior to surgery 2. Preoperative LUS score of >=2 in a single zone out of 12 zones 3. Preoperative shunt rate >= 10% 4. Progressive neuromuscular disease 5. Severe emphysema/COPD, large subpleural alveoli (>=2cm) 6. Intracranial hypertension 7. Participation in other clinical studies or refusal to participate in studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effectiveness of recruitment;Intraoperative mild hypoxemia;Death from any cause; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical power at the end of surgery;Time-weighted average mechanical power during surgery;The P/F ratio at the end of surgery;Dead space rate;Air-breathing test;Intraoperative hypotension;Intraoperative vasopressor use;Intraoperative severe hypoxemia;Lung ultrasound score (LUS) in the post-anesthesia care unit (PACU);Rate of respiratory failure at post-anesthesia care unit (PACU);Rate of postoperative respiratory failure;Rate of sustained hypoxaemia;Postoperative pulmonary complications, Grades 1–4;Postoperative pulmonary complications, Grades 2–4;Pneumothorax;Postoperative hospitalization days;Unexpected admission to ICU; | — |
Countries
China
Contacts
Public ContactHong Li
The Sixth Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed