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Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Fatigue Syndrome in Patients Undergoing Gynecological Laparoscopic Surgery: A Randomized Controlled Trial

Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Fatigue Syndrome in Patients Undergoing Gynecological Laparoscopic Surgery: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114736
Enrollment
Unknown
Registered
2025-12-17
Start date
2025-12-20
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Fatigue Syndrome after Gynecological Laparoscopic Surgery

Interventions

taVNS group:Receive 30 minutes of transcutaneous auricular vagus nerve stimulation (taVNS) treatment before surgery, as well as on the first and second postoperative days, respectively.
sham stimulation group:Receive 30 minutes of sham stimulation before surgery, as well as on the first and second postoperative days, respectively.

Sponsors

The First Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Signed informed consent form; 2. Patients scheduled for elective gynecological laparoscopic surgery under general anesthesia; 3. Aged 18-65 years; 4. American Society of Anesthesiologists (ASA) Physical Status Classification I-?; 5.Patients undergoing surgery with duration > 2 hours.

Exclusion criteria

Exclusion criteria: 1. Severe hepatic and renal insufficiency; 2. History of long-term opioid abuse; 3. Patients with severe central nervous system diseases; 4. Cervical vagus nerve injury; 5. Implanted cardiac pacemaker; 6. Cognitive impairment with inability to communicate.

Design outcomes

Primary

MeasureTime frame
10 - item Identity - Consequence Fatigue Scale;Visual Analogue Scale for Fatigue;

Secondary

MeasureTime frame
Heart Rate Variability;Postoperative Quality of Recovery Score;Athens Insomnia Scale (AIS);Numeric Rating Scale (NRS);Hospital Anxiety and Depression Scale;Visual Analog Scale;Postoperative Nausea and Vomiting Score;

Countries

China

Contacts

Public ContactZhang lei

The First Affiliated Hospital of Anhui Medical University

yfy1021010@fy.ahmu.edu.cn+86 139 6674 5097

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026