Postoperative pain
Conditions
Interventions
Group O:Oxycodone 20mg + Azasetron 10mg, diluted to 100ml with 0.9% normal saline. PCIA settings: Loading dose: 2ml, background infusion 0ml/h, bolus dose 2ml, lockout interval 15min, maximum dose 10m
Group S:Control group: Sufentanil 100ug + Azasetron 10mg, diluted to 100ml with 0.9% normal saline
PCIA settings: Initial dose: 2ml, background infusion 0ml/h, single press dose 2ml, lockout time 15min, maximum dose 10ml/h, continuous use for 48 hours.
Sponsors
Tongling People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) ASA grade I–III; (2) Aged 18–75 years, regardless of gender; (3) Scheduled for elective laparoscopic cholecystectomy under general anesthesia; (4) Preoperative resting pain score (NRS) <3; (5) Able to comprehend the study content and cooperate in using pain assessment tools (e.g., NRS score); (6) Intended to receive postoperative intravenous patient-controlled analgesia (PCIA); (7) Voluntarily participated in this study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Emergency surgery patients; (2) BMI >=35 kg/m²; (3) History of allergy or contraindication to study drugs (including oliceridine or local anesthetics such as ropivacaine); (4) Severe cardiac, pulmonary, cerebral diseases and/or abnormal liver or kidney function; (5) Cognitive impairment, mental illness, or current use of antipsychotic drugs; (6) History of alcohol or drug abuse, or long-term preoperative use of opioids or other analgesics; (7) Intraoperative conversion to laparotomy, occurrence of severe intraoperative complications, or surgical duration exceeding 90 minutes; (8) Inability to cooperate with postoperative follow-up and related assessments; (9) Refusal by family members or guardians to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve (AUC) of time-weighted pain scores (NRS, 0–10) during patient movement and rest within 0–48 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total postoperative opioid consumption (expressed in morphine equivalents) in the two groups, covering 0–24 h, 24–48 h, and 0–48 h;Number of postoperative analgesic pump presses;Time of first postoperative rescue analgesia, type of drug, and dosage;The occurrence of postoperative opioid-related adverse reactions, including PONV, sedation, pruritus, dizziness, and respiratory depression, etc.; | — |
Countries
China
Contacts
Public ContactGao Zongbin
Tongling People's Hospital
Outcome results
None listed