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Effects and Mechanisms of Ozonated Water on Postoperative Open Wound Healing in Patients with High Complex Anal Fistula: A Study Based on the MAPK Signaling Pathway

Effects and Mechanisms of Ozonated Water on Postoperative Open Wound Healing in Patients with High Complex Anal Fistula: A Study Based on the MAPK Signaling Pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114724
Enrollment
Unknown
Registered
2025-12-17
Start date
2023-09-17
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Complex Anal Fistula

Interventions

Experimental Group:Postoperative ozone irrigation and routine dressing change were performed
Control Group:Normal saline was used to wash the wound and routine dressing change was performed after operation

Sponsors

Affiliated Hospital of Jining Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients with anal fistula admitted to the Affiliated Hospital of Jining Medical University, Shandong Province, from September 2023 to December 2024. 2. Diagnosed with high-type complex anal fistula by MRI. 3. Patients aged 18 to 65 years.

Exclusion criteria

Exclusion criteria: 1. Patients who have undergone relevant surgical procedures or treatments within 7 days prior to admission; 2. Anal fistulas caused by specific infections, inflammatory bowel disease, or secondary infection from external injuries; 3. Patients with severe underlying diseases or immune dysfunction; 4. Patients with severe mental disorders or those unable to care for themselves;

Design outcomes

Primary

MeasureTime frame
Tumor necrosis factor-alpha;Interleukin-6;Vascular endothelial growth factor;Epidermal growth factor receptor;Transforming growth factor-ß;

Countries

China

Contacts

Public ContactDan Huang

Affiliated Hospital of Jining Medical University

huangdan9077@163.com+86 175 5370 1717

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026