Postoperative Cognitive Dysfunction
Conditions
Interventions
The group of Fospropofol disodium (Group F):Sufentanil 0.3 µg/kg was intravenously injected, and propofol disodium phosphate was diluted to 20 ml at a concentration of 10 mg/kg for intravenous infusio
Propofol group (Group P):Sufentanil was administered intravenously at a dose of 0.3 µg/kg, and propofol was diluted to 20 ml by a concentration of 1.5 mg/kg for intravenous infusion
Sponsors
The Affiated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age > 65 years old, gender not limited; 2. Scheduled laparoscopic surgery (Gastrointestinal surgery, Gynecology, Urology); 3.ASA Classification II-III grades; 4. The preoperative Mini-Mental State Examination (MMSE) score is greater than or equal to 24 points; 5. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Severe cardiovascular and cerebrovascular diseases (such as NYHA grade >=III or LVEF=160/100 mmHg); Has acute coronary syndrome or stroke occurred within 6 months 2. Abnormal liver and kidney functions (ALT, AST>2 times the upper limit, eGFR<60 ml/min/1.73m^2) 3. Long-term use of sedative/antidepressant drugs before the operation (more than 1 month); 4. Severe hearing impairment, visual impairment, and neuropsychiatric disorders that interfere with neuropsychological tests; 5. Allergic to propofol, disodium phosphopropofol or soybeans/eggs; 6. The operation time is less than 1 hour or more than 4 hours, and the intraoperative blood loss is greater than 15ml/kg or intraoperative blood transfusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence of postoperative cognitive dysfunction;Serum markers: Claudin-5, S100ß; | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection of serum markers;Duration of delirium, anesthesia recovery indicators (induction time, recovery time, extubation time), incidence of adverse reactions (hypertension, hypotension, injection pain, abnormal sensations, postoperative nausea and vomiting, etc.), dosage of vasoactive drugs;Electroencephalogram (EEG) monitoring indicators and non-invasive hemodynamic indicators; | — |
Countries
China
Contacts
Public ContactLiu Jing
The Affiliated Cancer Hospital of Guizhou Medical University
Outcome results
None listed