Allergic rhinitis
Conditions
Interventions
Experimental Group:Received 8 weeks of treatment with the Sipucibin antibody biological agent combined with 4 weeks of conventional medication treatment
Sponsors
The Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Applicants aged 18 to 60 (inclusive), with no gender restrictions; 2. The patient was diagnosed with moderate to severe chronic AR. Previous treatment with glucocorticoids had poor symptom control. 3. The patient tested positive for allergens (skin prick test or serum specific IgE test) (prick level >=++; sIgE level >= grade 2). 4. The patient can understand and sign the informed consent form; 5. The patient was able to actively comply with the protocol and accept follow-up.
Exclusion criteria
Exclusion criteria: 1. Patients with deviated nasal septum and other abnormal nasal structures, or those with a history of nasal surgery or trauma; 2. Combined with unstable asthma; 3. Women who are pregnant or breastfeeding; 4. Had an upper respiratory tract infection in the previous two weeks; Those with a history of severe systemic allergic reactions, immunosuppressive diseases (such as HIV infection history, etc.), malignant tumors, autoimmune diseases, tuberculosis, cardiovascular insufficiency or other serious organ system diseases as determined by the researcher. 5. Assess any other circumstances that are deemed unsuitable for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The nasal mucosal ciliary transit time at baseline and 8 weeks of treatment were compared;The rhinitis symptom-medication combination scores at baseline and 8 weeks of treatment were compared; | — |
Secondary
| Measure | Time frame |
|---|---|
| The allergic rhinitis quality of life questionnaire was compared at baseline, 8 weeks of treatment, and 12 weeks after drug withdrawal;Olfactory function was compared at baseline, 8 weeks of treatment, and 12 weeks after drug withdrawal;The nasal mucociliary transit time (MTT) and rhinitis symptom-drug combination score were compared 12 weeks after drug withdrawal; | — |
Countries
China
Contacts
Public ContactJiang Chenyan
The Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed