Breast cancer
Conditions
Interventions
Functional Exercise Matrix Program:The Functional Exercise Matrix intervention comprised the following components:
Warm-up: 5 minutes
Functional Exercise Matrix: 20 minutes
Cool-down: 5 minutes
Sponsors
Hainan Cancer Hospital??
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ??1. Diagnostic Criteria:?? Female patients with clinical stage IA-IIIA breast cancer, diagnosed according to the standards referenced in the Clinical Oncology Manual (6th Edition)edited by Shi Yuankai. 2. Age > 18 years and = 55%; absolute neutrophil count >= 2.0 × 10?/L; platelet count >= 100 × 10?/L; hemoglobin >= 10 g/dL. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 (An ECOG score of 2 indicates the patient is ambulatory and capable of all self-care but unable to carry out any work activities; up and about more than 50% of waking hours). Normal liver function (normal levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT)) and normal renal function (creatinine clearance > 60 mL/min). 6. Voluntarily provided signed informed consent. 7. Understood the study objectives and agreed to participate: able to complete questionnaires and willing to participate in the exercise training program.
Exclusion criteria
Exclusion criteria: 1. Any contraindication to sustained exercise or cardiopulmonary exercise testing; presence of conditions affecting ultrasound image quality, such as thoracic or spinal deformities or respiratory diseases. 2. Factors increasing the risk of anthracycline-induced cardiotoxicity (e.g., diabetes, dyslipidemia, hypertension, smoking, alcohol consumption, BMI > 35 kg/m²). 3. Pregnant or lactating women. 4. Previous history of chemotherapy or radiotherapy; concurrent participation in other interventional studies involving exercise training or cardioprotective drugs. 5. Expected survival 10% within the previous 3 months. 6. History of cardiovascular diseases, such as coronary artery disease, cardiomyopathy, valvular heart disease, or arrhythmia. 7. Use of >=2 classes of antihypertensive medications. 8. Others: Severe anemia (hemoglobin < 8 g/dL) not correctable by transfusion and/or supplementation of iron/vitamin deficiencies; active infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction, LVEF;NT-proBNP;?Godin Leisure-Time Exercise Questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hs-cTnT;The ratio of early diastolic mitral inflow velocity to early diastolic mitral annular velocity (E/e')??;The ratio of early to late diastolic mitral inflow velocities (E/A ratio)??;Left ventricular systolic diameter, LVESD;left ventricular end-diastolic diameter, LVEDD;VO2peak;6MWT;CancerFatigueScale;HADS;quality of life questionnaire for chinese cancer patients with chemobiotherapy; | — |
Countries
China
Contacts
Public ContactLiu Chunyu
Department of Rehabilitation Medicine, Hainan Cancer Hospital??
Outcome results
None listed