Stroke
Conditions
Interventions
Conventional treatment group:Exercise therapy, occupational therapy, physical factor therapy, and daily living activity training
TFUS intervention+conventional treatment group:The tFUS treatment uses a transcranial ultrasound therapy device (Beijing Ruao Medical Technology Co., Ltd., model: 880C) to stimulate the affected side
TMS intervention+conventional treatment group:TMS treatment uses a transcranial magnetic stimulation therapy device (Max company, model: TMS-100B), which acts on the primary motor cortex (M1) area of
Sponsors
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. 18 to 80 years old (including boundary values). 2. Meets the diagnostic criteria for stroke approved at the Fourth National Conference on Cerebrovascular Disease. 3. One hemisphere of the brain is affected, and the diagnosis is confirmed through head CT or MRI examination. 4. Vital signs are stable, consciousness is clear, and motor commands are acceptable. 5. The Brunstrom stage of the affected limb is stage I or above, and the muscle tone MAS grading is between grade 0 and grade 3. 6. Voluntarily participate in this study and sign an informed consent form. If the subject is unable to read and/or sign the informed consent form due to reasons such as lack of legal capacity, their guardian must act as a proxy for the informed process and sign the informed consent form. If the subject lacks the ability to read the informed consent form (such as illiterate subjects), a witness must witness the informed process and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of mental illness, intellectual disability, cerebrovascular disease, and organic brain disease before onset. 2. Cardiogenic cerebral infarction or extensive cerebral hemorrhage, transient ischemic stroke, and reversible stroke. 3. Patients with bilateral hemisphere injuries and those who have undergone cranial surgery other than minimally invasive thrombectomy after stroke onset. 4. Severe cardiovascular and pulmonary complications affect rehabilitation assessors and those with residual limb movement dysfunction from previous injuries. 5. Equipped with pacemakers, cochlear implants, or other metallic foreign objects in the body. 6. History of primary or secondary epilepsy. 7. Other vulnerable groups: critically ill patients, patients with cognitive impairment (MMSE score less than 23), pregnant women, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl Meyer Scale Evaluation;Near-infrared brain functional imaging assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional magnetic resonance imaging assessment;Brunnstrom stages;Modified Barthel Index,MBI; | — |
Countries
China
Contacts
Public ContactSong Haixin
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Outcome results
None listed