Complex Regional Pain Syndrome
Conditions
Interventions
Modified Bier block group:On the basis of conventional drug treatment, an improved Bier block method is adopted.
Pharmacological treatment group:First-line pharmacotherapy for neuropathic pain includes pregabalin at 150–300 mg per day. If pain relief is inadequate, tramadol is added.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for upper-limb CRPS (Budapest Criteria, revised 2010; 2. Age 18–65 years, regardless of sex; 3. Pain intensity VAS score >= 5; 4. CRPS duration > 3 months; 5. Voluntary participation, with informed consent signed by the patient and family members.
Exclusion criteria
Exclusion criteria: 1. Patients who have received neuromodulation treatments such as spinal cord stimulation or radiofrequency thermocoagulation; 2. Patients who have undergone nerve blocks within the past 3 months; 3. Known allergy to lidocaine, methylprednisolone, or mecobalamin; 4. Patients with moderate to severe pain in other body regions; 5. Patients with impaired upper-limb vascular circulation or coagulation disorders; 6. Patients with severe cardiac, pulmonary, hepatic, or renal disease, severe psychiatric disorders, or progressive malignant tumors; 7. Patients currently participating in other clinical trials involving investigational (unapproved) drugs or blinded clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brief Pain Inventory (BPI) ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment (FMA) for upper extremity motor function;Sympathetic skin response (SSR);Temperature difference in the painful area.;Patients’Global Impressions of Change (PGIC);Short Form-36 Health Survey;Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS);Pittsburgh Sleep Quality Index (PSQI); | — |
Countries
China
Contacts
Public ContactZheng Bixin
West China Hospital, Sichuan University
Outcome results
None listed