gastrointestinal tumor
Conditions
Interventions
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age >=65 years; 2. Patients scheduled for primary elective laparoscopic radical resection of gastrointestinal cancer under general anesthesia. 3. Postoperative length of stay >= 3 days.
Exclusion criteria
Exclusion criteria: 1. Preoperatively unable to communicate due to cognitive impairment or language impairment; 2. Preoperative history of chronic pain or opioid abuse; 3. A history of drug abuse and/or alcohol abuse within the past 3 months; 4. Patients who are expected to be unable to assess pain intensity postoperatively or transferred to the ICU; 5. Abnormal liver and renal function; 6. Patients who have contraindications to or are allergic to the study drugs (oliceridine, sufentanil) and other related drugs; 7. Patients with respiratory depression or those at high risk of respiratory depression (e.g., obstructive sleep apnea syndrome); 8. Patients with craniocerebral injury, possible intracranial hypertension, cerebral aneurysm, history of cerebrovascular accident, or suffering from central nervous system diseases (e.g., epilepsy); 9. Patients with mental system diseases (e.g., depression) or those on long-term use of psychotropic drugs; 10. Electrocardiogram (ECG) shows QT interval prolongation; 11. Patients who have participated in clinical studies of other drugs or medical devices within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events;short-term and long-term postoperative cognitive function;Postoperative sleep quality;Postoperative sedation score;Postoperative quality of recovery;Rescue analgesic usage;Postoperative biochemical indicators;Gastrointestinal reactions;Pain Scores; | — |
Countries
China
Contacts
Public ContactJiru Zhang
Affiliated Hospital of Jiangnan University
Outcome results
None listed