HPV-related cervical cancer
Conditions
Interventions
Early-stage (stage I-II) cervical cancer patients :N/A
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Pathologically confirmed cervical cancer (of any histological type); 2.Including: CIN II and CIN III; and early-stage cervical cancer patients clinically staged as (stage I-IIA); 3.Healthy control group consisting of HPV-negative healthy individuals; 4.PCR detection of cervical exfoliated cells or serum confirmed as positive for high-risk HPV genotypes; 5.Excluding the healthy control group, all patients have undergone surgical treatment; 6.Patients with risk factors after cervical cancer surgery will receive postoperative radiotherapy or chemoradiotherapy according to guidelines; 7.Clinical residual serum or plasma samples collected, 0.5 ml per sample; 8.KPS score >= 70; 9.Age 18-80 years; 10.ECOG performance status score of 0-2; 11.atients are all treatment-naive, with no previous chemotherapy or radiotherapy; 12.Availability for follow-up.
Exclusion criteria
Exclusion criteria: 1.Cervical cancer patients with no pathological support for the primary lesion; 2.Cases where double or multiple primary tumors cannot be excluded; 3.Patients with a history of, or currently diagnosed with, any other malignancies; 4.Low-risk HPV infection; 5.PCR detection of HPV genotyping in cervical cancer tissue, cervical exfoliated cells, and serum all show HPV negative; 6.The investigator deems the patient unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum/Plasma HPV Cell-Free DNA (cfDNA); | — |
Countries
China
Contacts
Public ContactZhuomin Yin
Zhejiang Cancer Hospital
Outcome results
None listed