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Intrathecal injection of nalbuphine for improving postoperative pain after anorectal surgery—a randomized controlled double-blind study

Intrathecal injection of nalbuphine for improving postoperative pain after anorectal surgery—a randomized controlled double-blind study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114652
Enrollment
Unknown
Registered
2025-12-16
Start date
2025-12-31
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain of anorectal surgery under single spinal anesthesia

Interventions

Control group:Received 0.5% bupivacaine 2ml and 0.5ml normal saline subarachnoid injection
Fentanyl-bupivacaine group :Intrathecal injection of 0.5% bupivacaine (2 ml) plus fentanyl (25 µg / 0.5 ml)
Nalbuphine-bupivacaine group :Intrathecal injection of 0.5% bupivacaine (2 ml) plus nalbuphine (1 mg / 0.5 ml)

Sponsors

The First Affiliated Hospital of Henan University of CM
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Voluntarily participate in this study and sign the informed consent form; 2. Patients at our hospital planning to undergo anorectal surgery under spinal anesthesia; 3. Aged 18–60 years; 4. ASA class I–II; 5. BMI between 18 and 26 kg/m^2.

Exclusion criteria

Exclusion criteria: 1.Known allergy to local anesthetics or opioids. 2.Patients with hepatic or renal insufficiency. 3.Severe cardiac or neurological diseases. 4.Spinal deformity or local skin infection at the site of lumbar puncture. 5.Presence of psychiatric disorders that would preclude cooperation. 6.Hemorrhagic tendency or coagulation disorders. 7.Participation in any other drug or device clinical trial within the last 3 months.

Design outcomes

Primary

MeasureTime frame
Visual Analogue Scale;Duration of sensory block;Duration of motor block;

Countries

China

Contacts

Public ContactLiang Jingguang

The First Affiliated Hospital of Henan University of CM

328380659@qq.com+86 151 3869 1957

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026