None
Conditions
Interventions
Control group (general anesthesia group):After the patient entered the operating room, vital signs were monitored, peripheral venous access was opened, no special provisions were made for muscle relax
Experimental group (general anesthesia combined with serratus anterior block (0.65% bupivacaine liposome +0.1875% bupivacaine hydrochloride injection)):After the patient was admitted to the operating
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 years and <=80 years, any gender; 2.Patients undergoing thoracoscopic lung resection surgery; 3.ASA classification of grade I or II; 4.Clearly understand and voluntarily participate in the study, with informed consent signed by themselves or their family members.
Exclusion criteria
Exclusion criteria: 1.Expected surgery time >=3 hours; 2.Severe heart diseases such as serious arrhythmia, heart failure, Adams-Stokes syndrome, unstable angina, myocardial infarction within the past 6 months, history of tachycardia/bradycardia requiring medication, third-degree atrioventricular block, or QTcF interval >=450ms (corrected by Fridericia’s formula), or exercise tolerance =180 mmHg and/or diastolic pressure >=110 mmHg measured upon entering the operating room; 4.Respiratory insufficiency, history of severe obstructive or restrictive lung diseases, bronchospasm requiring treatment within the past 3 months, acute respiratory infection within the past week with symptoms such as significant fever, wheezing, nasal congestion, and cough; 5.Uncontrolled clinically significant diseases of the liver, kidneys, blood, nervous system, or metabolic disorders that may be deemed unsuitable for study participation by the researcher; 6.Pregnant or breastfeeding women; 7.Known allergy to opioids, local anesthetics, or other anesthetic drugs; 8.Participation in another clinical drug trial within the past 3 months; 9.History of cranial injury, potential seizures, myoclonus, intracranial hypertension, cerebral aneurysm, cerebrovascular accident, schizophrenia, intellectual disability, mania, psychosis, long-term use of psychiatric medication, drug addiction, or cognitive dysfunction; 10.Patients deemed unsuitable for the trial by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia-related adverse events within 48 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative opioid dosage;Postoperative patient pain scores;Opioid analgesic use in postoperative patients;Postoperative patient satisfaction with analgesia; | — |
Countries
China
Contacts
Public ContactZhang Li
Zhongshan Hospital, Fudan University
Outcome results
None listed