All patients over 60 years old who need to undergo general anesthesia surgery
Conditions
Interventions
Titration group:Administer the first dose of sugammadex sodium 50 mg immediately after surgery. Thereafter, repeat sugammadex sodium 50 mg every 5 minutes. Repeat this process until TOFR consistently
Recommended dose group:1. Assess the depth of neuromuscular blockade:
If PTC >= 1, give sugammadex sodium 4 mg/kg.
If TOF count >= 2, give sugammadex sodium 2 mg/kg.
2. 5 min
Sponsors
Sichuan University Affiliated Chengdu Second People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Age > 60 years. ASA classification I-III. Scheduled to undergo non-cardiac surgery under general anesthesia. Informed consent obtained.
Exclusion criteria
Exclusion criteria: Allergy to sugammadex sodium or its components, or to rocuronium bromide. Severe hepatic or renal dysfunction (Child-Pugh class C or eGFR 35 kg/m². Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the dose of sugammadex;Muscle contraction recovery time; | — |
Secondary
| Measure | Time frame |
|---|---|
| paralysis reappears;Tracheal extubation time;adverse reactions; | — |
Countries
China
Contacts
Public ContactCai Shu
Sichuan University Affiliated Chengdu Second People's Hospital
Outcome results
None listed