Eczematous psoriasis
Conditions
Interventions
Experimental Group:Combined treatment with JAK inhibitor and IL-17A inhibitor
Control Group:IL-17A inhibitor treatment
Sponsors
The First Affiliated Hospital of Army Medical University of the People's Liberation Army of China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-65 years old; 2. Patients clinically diagnosed with eczematous psoriasis and requiring systemic treatment must meet one of the following conditions: 1) Body surface area (BSA) involvement >=3%, and/or PASI score >=3 points; 2) EASI score >7, body surface area (BSA) involvement >5% and/or pruritus score (NRS) >=4; 3. For those who have recently received systemic treatments such as hormones, methotrexate, acitretin, cyclosporine, etc., elution is required for A period of 4 weeks. 4. The patient has good compliance with the planned treatment, and the patient (or their guardian) can understand the research process of this study and sign the written informed consent form. 5. Voluntarily participate in this study and be willing to randomly receive two treatment methods.
Exclusion criteria
Exclusion criteria: 1. There are secondary infections, ulcers or other skin lesions of skin diseases that affect the judgment of treatment effect at the local lesion site; 2. Patients with severe diabetes, coronary heart disease and other underlying diseases, as well as those with thrombosis, severe infections, malignant tumors, connective tissue diseases, tuberculosis and other diseases that are not suitable for the use of biological agents; The exclusion criteria for infectious diseases are as follows: a. Within 14 days before the screening period, any of the following conditions exist: acute systemic infection symptoms (such as fever (axillary body temperature >=38.0?), chills) occur, or peripheral blood WBC > 12×10^9/L and Neu% > 75%, or etiological confirmation of systemic infection (such as positive blood culture); b. Respiratory tract infection: Those who had acute upper respiratory tract infection, acute bronchitis (cough with purulent sputum, chest X-ray showing thickened lung texture), or pneumonia (chest X-ray/CT showing pulmonary exudation foci) within 14 days before the screening period; c. Urinary and reproductive system infections: Those who had acute cystitis (frequent urination, urgent urination, painful urination, urine routine: white blood cells > 10 /HPF) or pyelonephritis (accompanied by fever, positive urine culture) within 14 days before the screening period; d. There are active skin infections, such as skin and soft tissue infections (erysipelas, cellulitis), shingles, herpes simplex; e. Systemic antibiotics (such as cephalosporins, quinolones) have been used within 14 days prior to the screening period, and the infection-related symptoms have not been completely relieved; f. Tuberculosis, meeting one of the following criteria: previously diagnosed active tuberculosis (i.e., having a history of tuberculosis), having completed or not having completed standardized anti-tuberculosis treatment; Chest X-ray/chest CT indicates active pulmonary tuberculosis lesions. Tuberculosis is positive by ? -interferon release assay or T-SPOT detection; g. Other chronic infections: active hepatitis B (positive for HBsAg and HBV DNA), active hepatitis C (positive for HCV RNA), AIDS (positive for HIV antibodies), and active mycosis (such as candidemia and aspergillosis, which need to be confirmed by etiology or imaging). 3. People who are addicted to alcohol, drugs or have mental disorders; 4. Patients judged by the researchers as unsuitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psoriasis Area and Severity Index score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Digital Pruritus Score (NRS);Eczema Area and Severity Index score; | — |
Countries
China
Contacts
Public ContactZhiqiang Song
The First Affiliated Hospital of Army Medical University of the People's Liberation Army of China
Outcome results
None listed