hypoactive Emergence Delirium,POD
Conditions
Interventions
Active Group:Perform real TACs on patients in the postoperative monitoring room. Electrical stimulation is carried out by 2 electrodes placed in a sponge soaked in salt water. The electrode is fixed b
Anhui Hefei Brainqi Medical Technology Co., Ltd. Patients in the true TACs group received stimulation that lasted for 20 minutes, with a frequency of 40Hz and a current intensity of 2.0Ma.
Sham Group:Pseudo-TACs are performed on patients in the postoperative monitoring room. Electrical stimulation is carried out by 2 electrodes placed in a sponge soaked in salt water. The electrode is f
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age 65-90 years old; 2. ASA Grade II~Grade III; 3. No more than 2 hours during the operation; 4. Patients with normal cognitive function before surgery (MoCA score >=24); 5. Patients who intend to undergo elective non-cardiac and non-neurosurgical surgery; 6. Agree to participate in this research and sign an informed consent form
Exclusion criteria
Exclusion criteria: 1. Patients with a life expectancy of 6 months; 2. Have a history of mental illness or a history of nervous system diseases (including depression, severe central nervous system depression, schizophrenia, epilepsy, Parkinson's disease or Alzheimer's disease); 3. Major obstacles that may hinder cognitive testing, such as blindness, severe deafness or dementia; 4. Have used psychotropic drugs or opiate drugs, have a history of delirium before surgery; 5. Have a record of alcohol abuse or abstinence in the past 6 months; 6. Coma or dementia leads to inability to communicate effectively before surgery; 7. Participating in another clinical trial; 8. Body mass index (BMI) >=29kg/m^2 or<=18kg/m^2; 9. Plan to have another operation within 7 days after the first operation; 10. Patients with epilepsy or other abnormal EEG activity in the past; 11. Absolute contraindications for patients with tDCS include: implantable electronic devices (such as pacemakers, deep brain stimulators (LBS), vagus nerve stimulators (VNS), cochlear implants, programmable implantable pumps, and other electronic nerve regulation devices) intracranial metal implants, Uncontrolled epilepsy, severe skull defects, etc.;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium;Incidence of indifferent delirium during postoperative awakening; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative incidence of postoperative delirium;Incidence of severe delirium;Postoperative cognitive impairment (POCD) on the 7th day after surgery or at the time of discharge (if earlier);Cognitive function one month after surgery;30-day all-cause mortality rate;Improvement of directional dysfunction in patients with indifferent delirium during postoperative awakening;Postoperative anxiety-depression score;Functional near-infrared spectroscopy brain imaging brain area activation and connection changes;Time from the end of the operation to the appearance of delirium;Duration of delirium;The sum of the number of delirium-positive days in patients with delirium;Resting and exercise NRS score;Postoperative extubation time;Re-admission to the intensive care unit within 30 days after the operation;Number of days to live within 30 days and be discharged from the hospital;Sleep quality score;Incidence and severity of postoperative nausea and vomiting (PONV);Incidence of complications after surgery;Hospitalization expenses; | — |
Countries
China
Contacts
Public ContactLiu Xuesheng
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed