Efficacy of Vagus Nerve Stimulation Combined with Rehabilitation Training for Hemiplegia After Intracerebral Hemorrhage: A Single-Arm Clinical Trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500114570

Enrollment

Unknown

Registered

2025-12-15

Start date

2026-01-01

Completion date

Unknown

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disorders of consciousness (DOC)

Interventions

TI Stimulation Group:Temporal Interference Electrical Stimulation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Age 18-85 years; 2.DOC patients diagnosed with vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally conscious state (MCS) by CRS-R; 3.Intact skin at the stimulation site; 4.Stable vital signs; 5.Informed consent obtained and signed by family members.

Exclusion criteria

Exclusion criteria: 1.Active elevated intracranial pressure; 2.Intracranial metal implants, implanted cardiac pacemakers, or cochlear implants; pregnancy or lactation; 3.History of alcohol/substance abuse or neuropsychiatric disorders; 4.Uncontrolled epilepsy patients who have taken antiepileptic drugs within the past month; 5.Use of general anesthetics (e.g., propofol) or central sedatives (e.g., benzodiazepines, opioids).

Design outcomes

Primary

Measure	Time frame
EEG Alpha Band Power Spectrum;	—

Secondary

Measure	Time frame
CRS-R Assessment Score;Functional Connectivity Characteristics of Magnetoencephalography;	—

Countries

China

Contacts

Public ContactYanwu Guo

Zhujiang Hospital of Southern Medical University

dguoyanwu@163.com+86 137 1143 2687

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Sep 5, 2026