chronic kidney disease stage 5, hemodialysis
Conditions
Interventions
Experimental group:Hemodialysis + hemoperfusion (pHA130 perfusion device)
Control group:hemodialysis
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-80 years, gender not limited; (2) Stable maintenance hemodialysis for >=3 months, with a relatively fixed dialysis pattern; (3) Hemodialysis treatment 3 times a week, with a total treatment time of >=10 hours per week, vascular access not limited; (4) SDS score >=53; (5) Kt/v >= 1.2 in the 12 weeks prior to selection; (6) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with known allergies, contraindications, or intolerance to the materials used in the dialyzer or perfusion apparatus; (2) Patients whose laboratory indicators meet one or more of the following criteria: white blood cell count < 4 × 10?/L, platelet count < 60 × 10?/L, serum albumin < 30 g/L; (3) Patients with a blood flow rate < 200 ml/min; (4) Patients who have received regular hemoperfusion therapy for more than 3 consecutive months and at least once a week; (5) Patients with grade 4 chronic congestive heart failure according to the New York Heart Association classification; (6) Individuals with acute infections, severe heart, lung, liver, or nervous system diseases, or malignant tumors; (7) Pregnant or breastfeeding individuals; (8) Individuals who have participated in or are currently participating in clinical trials within the past 3 months; (9) Individuals with an expected survival of less than 1 year; (10) Individuals deemed unsuitable for this trial by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| depression score; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum ß2-MG;PTH;CRP;IL-6;TNF;Indoxyl sulfate;p-Cresyl sulfate;life quality;sleeping quality;itching; | — |
Countries
China
Contacts
Public ContactQing Yu, Minchao Cai
Shanghai General Hospital
Outcome results
None listed