Adolescent idiopathic scliosis
Conditions
Interventions
Experimental Group One:Experimental Group 1 received a 50mg/kg intravenous infusion of TXA (diluted in 100ml saline) 15 minutes prior to surgical skin incision. During surgery, a maintenance dose of 1
Experimental Group Two:Experimental Group 2 received a 50mg/kg intravenous infusion of TXA (diluted in 100ml saline) 15 minutes prior to surgical skin incision. During surgery, a maintenance dose of 1
once mixed, indistinguishable from saline solution by visual inspection
barutine dosage selected based on graft fusion segments: 1 U of Barutine is required for two segments. For odd numbers of segments, apply rounding rules: 9/11/13/15 segments require 5U/6U/7U/8U respec
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 10 to 18 years diagnosed with AIS who underwent PSSF surgery. 2. Patients or their families consented to participate in this study and signed the relevant informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe underlying cardiovascular or cerebrovascular conditions unsuitable for surgery; 2. Patients with severe anaemia or coagulation disorders prior to surgery; 3. Individuals allergic to tranexamic acid (TXA) or bartitin; 4. Patients with severe hepatic or renal insufficiency; 5. Those with a history of thrombosis; 6. Patients still taking anticoagulants (e.g., aspirin) within two weeks prior to surgery; 7. Intraoperative dura mater injury resulting in cerebrospinal fluid leakage; 8. Patients and their families who refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in fibrinolytic parameters;Occult blood loss;Postoperative drainage volume;Maximum haemoglobin loss;Length of hospital stay;Incidence of complications; | — |
Countries
China
Contacts
Public ContactLiu Limin
West China Hospital, Sichuan University
Outcome results
None listed