None
Conditions
Interventions
Experimental Group 1:Commercial sugar-free coffee products, prepared with plain boiled water
Control group:The daily beverage is plain boiled water
Experimental Group 2:Commercial low-caffeine coffee products, prepared with plain boiled water
Sponsors
The Seventh Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–65 years, regardless of sex; 2.No severe chronic diseases and a stable health condition in the recent period (within the past 3 months); 3.Has good compliance, is willing to cooperate with the study procedures, and has signed the informed consent form; 4.Able to comply with all examinations and follow-up arrangements during the study;
Exclusion criteria
Exclusion criteria: 1.Previous diagnoses include diabetes, coronary heart disease, cerebrovascular disease, severe hepatic and renal dysfunction, and digestive system diseases (such as peptic ulcers, etc.); 2.Pregnant and breastfeeding women; 3.Use of, or currently taking, medications that affect the gut microbiota or metabolic function within the past month, such as antibiotics, probiotics, prebiotics, hormonal drugs, or immunosuppressants; 4.Those with a history of caffeine allergy or who experience severe adverse reactions to caffeine; 5.Currently participating in, or planning to participate in, other clinical trials during the study period; 6.History of mental illness or poor mental status, unable to cooperate with the study; 7.Individuals with an extreme dietary pattern or extreme exercise habits (such as strict vegetarians, athletes, etc.); 8.Patients with autoimmune diseases; 9.Any other situations that the investigators consider unsuitable for participation in this trial;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the body’s immune status; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the gut microbiota;Fasting blood glucose;Complete blood count;Four blood lipid indices;Insulin;Changes in body metabolism; | — |
Countries
China
Contacts
Public ContactBin Xia
The Seventh Affiliated Hospital Sun Yat-sen University
Outcome results
None listed