Pre-hypertension(130~139/80~89mmHg)
Conditions
Interventions
Intervention group:RAS inhibitors and health education
Control group:Health education
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. During the screening period, the mean blood pressure of two consulting rooms at different time points (different days, less than 1 week apart) met: SBP<140 mmHg and DBP<90 mmHg, 120mmHg<=SBP<=139mmHg and/or 80mmHg<=DBP<=89 mmHg; 2. Age 30-65 years old (30 <= age<65 years old); 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Having taken antihypertensive drugs within two weeks before enrollment. 2. History of stroke (excluding lacunar infarction and transient ischemic attack). 3. History of acute myocardial infarction or unstable angina; history of blood vessel reconstruction surgery (PCI or CABG). 4. Severe liver or kidney disease, hyperkalemia (ALT>=3 times the upper limit of normal; patients undergoing dialysis or with an estimated glomerular filtration rate [eGFR] =5.5mmol/L). 5. Presence of persistent atrial fibrillation or arrhythmias that affect blood pressure measurement by electronic sphygmomanometer. 6. Presence of other serious diseases that may hinder enrollment or affect survival, such as malignant tumors or AIDS. 7. Presence of cognitive dysfunction or inability to take care of oneself. 8. Pregnant or breastfeeding, or planning to become pregnant. 9. Post - organ transplant. 10. Currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brachial-ankle pulse wave velocity, baPWV;Primary composite cardiovascular end points; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stroke (cerebral infarction, cerebral hemorrhage);Acute Myocardial Infarction;Unstable angina pectoris;Revascularization treatment of the coronary artery (stent or bypass surgery);Cardiovascular death;All-cause mortality;Progress to high blood pressure;New-onset diabetes;Kidney outcome;Newly diagnosed malignant tumor;Health economics evaluation;Left ventricular hypertrophy;Intima-media thickening of the common carotid artery;Acute Heart Failure;New-onset atrial fibrillation; | — |
Countries
China
Contacts
Public ContactKuang Zemin
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed