Tachycardia
Conditions
Interventions
Landiolol group:In the landiolol group, an initial loading dose of 0.1 mg/kg was administered by intravenous infusion over 1 minute, followed by titration of the maintenance infusion rate between 1 an
Esmolol group:In the esmolol group, an initial loading dose of 0.5 mg/kg was administered by intravenous infusion over 1 minute, followed by titration of the maintenance infusion rate between 0.05 and
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age >= 18 years old; (2) Develops tachycardia within 72 hours after admission, with heart rate > 100 beats per minute; (3) Only uses landiolol or esmolol, and does not use other anti-arrhythmic drugs.
Exclusion criteria
Exclusion criteria: (1) Women who are pregnant or breastfeeding; (2) Allergic to beta-blockers or having contraindications to esmolol and landiolol such as severe sinus tachycardia, sick sinus syndrome, second or third degree atrioventricular block, hypotension, uncorrected metabolic acidosis, cardiogenic shock, pulmonary hypertension, uncontrolled pheochromocytoma and acute asthma attack, etc.; (3) Currently using positive inotropic drugs; (4) Had been taking beta-blockers for a long time before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tricuspid valve systolic displacement, TAPSE;Mitral valve systolic displacement, MAPSE;Left ventricular ejection fraction, LVEF; | — |
Countries
China
Contacts
Public ContactZhou Jing
The First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed