Port wine CM
Conditions
Interventions
Observation group 1 (8-18 years):None
Observation group 2(19-60 years):None
Observation group 3(2-7 years):None
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
2 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 2-60 years old (including upper and lower limits); 2. Clear diagnosis of port-wine stain; 3. It can include isolated PWS and related syndromes such as Sturge-Weber syndrome (SWS), phakomatosis pigmentovascularis (PPV), etc. The erythema should be relatively isolated from the other lesions of the syndrome, that is, there are no other related skin pathological changes at the site of the erythema, such as dermal melanocytosis. 4.The interval between photodynamic therapy and the last erythema treatment was at least 3 months; 5. After fully understanding the protocol and risks, I or my guardian will sign the informed consent form voluntarily.
Exclusion criteria
Exclusion criteria: 1. Infection, eczema, ulcer, or other pigmented diseases such as nevus of Ota at the lesion site; 2. History of seizures or uncontrolled seizures in the past six months; 3. Allergy to porphyrins or allergic constitution; 4. Scar constitution; 5. A history of sun exposure in the past 3 months; 6. There are potential diseases such as abnormal electrocardiogram, organic heart disease, abnormal liver function, pregnancy or pregnant women that may affect treatment; 7. Refuse blood collection or fail to cooperate with the blood collection process; 8. Recent use (within 1 month) of drugs that affect the study drug metabolism, or combined with serious underlying diseases that may interfere with drug metabolism (such as inherited metabolic diseases); 9. Persons participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drug concentration; | — |
Countries
China
Contacts
Public ContactMa Gang
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed