Pulmonary nodule,Lung cancer,Mediastinal mass
Conditions
Interventions
B Group(Esketamine combined with Butorphanol tartrate PCA group):The solution for Group B contained esketamine 1.0mg/kg and butorphanol tartrate 8-12mg. For both groups, ramosetron 0.9mg was added, an
S Group (Esketamine Combined with Sufentanil PCA group)):In the esketamine (1.0 mg/kg) and sufentanil (1.5 µg/kg) groups, ramosetron 0.9 mg was added to each patient-controlled analgesia (PCA) pump an
Sponsors
The Second Hospital of Dalian Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing thoracic surgery under general anesthesia with postoperative PCA; 2.Female patients aged 18–80 years; 3.ASA physical status classification I–III; 4. BMI 18–28 kg/m^2; 5. No severe cardiovascular disease, hepatic or renal dysfunction, or impaired consciousness before surgery; 6.Fully awake with restored orientation, cooperative with physical examination, and able to communicate normally at 6 hours postoperatively; 7. Patients who provided informed consent for this study.
Exclusion criteria
Exclusion criteria: 1. Severe hepatic or renal dysfunction, or severe cardiovascular and cerebrovascular diseases; 2. Postoperative admission to the ICU; 3. History of psychiatric disorders or preoperative cognitive impairment; 4.Postoperative agitation, impaired consciousness, or inability to cooperate; 5.Long-term use of opioid analgesics or other pain-relief medications; 6.Incomplete or missing postoperative follow-up records; 7.Unwillingness to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nausea and Vomiting Scale;Incidence of nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score;Sedation Score;Adverse Event;Time to First Flatus;The first time you walk after surgery;48-hour analgesic pump effective presses;Number of rescue analgesic dose;48-hour analgesic pump effective presses;Incidence of postoperative complications; | — |
Countries
China
Contacts
Public ContactZhou Feng
The Second Hospital of Dalian Medical University
Outcome results
None listed