Major Depressive Disorder
Conditions
Interventions
Intervention group:Vitamin D supplementation
Control group:None
Sponsors
The Second Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1 Inpatients admitted to our hospital who meet the diagnostic criteria for Major Depressive Disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 2 Aged 12-18 years; 3 With a Children's Depression Rating Scale-Revised (CDRS-R) score of >= 40; 4 With a serum 25-hydroxyvitamin D [25(OH)D] level of = 12 ng/ml) and a deficiency group (<12 ng/ml).
Exclusion criteria
Exclusion criteria: 1 Patients diagnosed with other psychiatric disorders per DSM-5 criteria, such as schizophrenia, bipolar depression, substance use disorder, or other mental disorders; 2 Those with concurrent infections, autoimmune diseases, or other severe systemic medical conditions; 3 Diseases affecting vitamin D metabolism (e.g., sarcoidosis, hypoparathyroidism, hyperparathyroidism, hypercalcemia, kidney stones, renal failure, or other conditions impairing renal function); 4 Pregnant individuals; 5 Patients with a significant risk of suicide; 6 Recent use of vitamin D-containing medications or supplements; 7 Individuals with intellectual disability unable to cooperate with the assessment; 8 Known allergy to vitamin D or any excipients in its formulations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;CRP; | — |
Countries
China
Contacts
Public ContactLeiyin Chen
The Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed