Digestive system tumors
Conditions
Interventions
Experimental group:Drug: Oliceridine.
Dose: 0.15-0.3 µ g/kg/min, adjust the dose according to the patients pain level.
Administration method: Continuous intravenous infusion.
Medication time: 24-48 ho
Control group:Drug: Fentanyl.
Dosage: 0.1-0.2 µ g/kg/min. Adjust the dosage according to the patients pain level.
Administration method: Continuous intravenous infusion.
Medication time: 24-48 hours a
Sponsors
Tianjin Cancer Hospital Airport Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: Age: 40-90 years old. Diagnosis: The patient was pathologically diagnosed as a tumor of the digestive tract (such as gastric cancer, colorectal cancer, pancreatic cancer, etc.) and received surgical treatment. Postoperative situation: After surgery, the patient was transferred to the ICU for monitoring and treatment. ASA classification: I-II (American Society of Anesthesiologists classification). Informed consent: Patients or their families sign an informed consent form and voluntarily participate in the study.
Exclusion criteria
Exclusion criteria: Expected survival period:<4 months. Severe organ dysfunction: such as liver and kidney failure, heart failure, etc. Drug contraindications: Allergies to opioid drugs or contraindications to use. Long term use of opioid drugs before surgery, such as long-term use of analgesics such as morphine and fentanyl. Other: Existence of mental illness or cognitive impairment, inability to cooperate with research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score, NRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of vomiting;Length of ICU stay;Incidence of respiratory depression;The impact of heart rate and blood pressure; | — |
Countries
China
Contacts
Public ContactRui Xia
Tianjin Cancer Hospital Airport Hospital
Outcome results
None listed