Chronic kidney disease
Conditions
Interventions
Observation group:Conventional treatment combined with Roxadustat
If the patients Hb increases > 20g and the Hb value is > 90g within 2 weeks, the dose should be reduced by one step.
When HB rises to
Control group:Conventional treatment combined with erythropoietin
Sponsors
The First Affiliated Hospital of Anhui University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The clinical diagnosis of non-dialysis patients meets the diagnostic criteria of chronic kidney disease; 2. Age >= 18 years old; 3.The dialysis patients need regular hemodialysis treatment for >= 3 months, 4 hours each time, 3 times per week; 4. Patients should know and sign informed consent form, and report to the hospital ethics committee for approval before implementation.
Exclusion criteria
Exclusion criteria: 1. Severe abnormal cardiopulmonary function; 2.Pregnancy or lactation; 3.Patients complicated with other primary endocrine diseases (such as hyperthyroidism), malignant tumor, blood system diseases or severe malnutrition; 4. Those who have a history of nervous system or mental illness and cannot successfully complete the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fibroblast growth factor(FGF23);calciprotein(CCP);a-klotho protein;Serum Calcium;Serum phosphorus;Hemoglobin; | — |
Secondary
| Measure | Time frame |
|---|---|
| parathyroid hormone(PTH);blood fat;C-reactive protein((CRP); abdominal aortic calcification(AAC) ; | — |
Countries
China
Contacts
Public ContactJiamei Di
The First Affiliated Hospital of Anhui University of Science and Technology
Outcome results
None listed