gastric cancer
Conditions
Interventions
S1 group:Postoperative analgesic pump formula: 3 µg/kg sufentanil + 16 mg ondansetron + normal saline
S2 group:Postoperative analgesic pump formula: 2.5 µg/kg sufentanil + 2.4 µg/ml dexmedetomidine + 16 mg ondansetron + normal saline
SN group :Postoperative analgesic pump formula: 2 µg/kg sufentanil + 1 mg/kg nalbuphine + 2.4 µg/ml dexmedetomidine + 16 mg ondansetron + saline
Sponsors
Anhui Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1. No gender restrictions, aged 60–74 years; 2. BMI: 18.5–24.0 kg/m²; 3. ASA anaesthesia classification II–III; 4. Patient consents to postoperative use of an electronic analgesic pump; 5. Voluntarily signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with known hypersensitivity to nalbuphine hydrochloride or any of its constituents, or with a history of opioid allergy; 2. Use of analgesic sedatives, antiemetics, or antihistamines within 24 hours prior to surgery; 3. Patients with a history of prolonged use of sedative-analgesic medications; 4. Patients anticipated to require admission to the ICU postoperatively; 5. Renal impairment (blood urea nitrogen and/or creatinine > upper limit of normal reference range); hepatic impairment (aspartate aminotransferase and/or alanine aminotransferase > 1.5 times upper limit of normal reference range).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery Quality Scale (QoR-15) score ;Adverse reaction rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incision and visceral VAS pain scores ;QoR-15 score;Self-rating Anxiety Scale (SAS) scores;Pittsburgh Sleep Quality Index (PSQI) scale score; | — |
Countries
China
Contacts
Public ContactTang Chaoliang
Anhui Provincial Cancer Hospital
Outcome results
None listed