Gastric cancer
Conditions
Interventions
Stable exercise group :None
Inactive group:None
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. Gastric malignancy confirmed by histology or cytology; 3. no contraindication to chemotherapy, receiving neoadjuvant chemotherapy, and having a clear intention of radical surgery; 4.ECOG score 0-1, Karnofsky score >= 70, or ability to complete a physical function test such as 6-minute Walk Test > 400 meters; 5. Conscious, no communication disorder, able to understand the research content and complete motor commands; 6. Volunteer to participate in this study and have signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Distant metastasis (stage IV); 2. other antineoplastic therapy before NAC or preoperative preparation; 3. Plan for non-radical surgery; 4. combined with other malignant tumors; 5. Acute or chronic diseases judged by the attending physician to be unsuitable for exercise, such as severe arthritis, neurological diseases, heart failure NYHA class III-IV, uncontrolled severe respiratory diseases, etc. 6. Severe, uncontrolled pain (NRS >=7) caused by the tumor itself or the treatment; 7. Any history of mental illness, poor compliance, and inability to understand and cooperate with the study protocol; 8. Participate in other interventional clinical studies that may interfere with the outcomes of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of exercise steps; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chemotherapy tolerance: Incidence and severity of myelosuppression (neutropenia, thrombocytopenia, anemia);Chemotherapy efficacy: Tumor response classification and clinical downstaging rate;Postoperative outcomes: Operative time, intraoperative blood loss, number of lymph nodes dissected, incidence and severity of postoperative complications (Clavien-Dindo classification), duration of drainage tube placement, time to first flatus, time to initiation of liquid diet, and length of postoperative hospital stay;Long-term prognosis: Overall survival; | — |
Countries
China
Contacts
Public ContactYuan Wenzhen
The First Hospital of Lanzhou University
Outcome results
None listed