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Association of COMT gene polymorphism with perinatal anxiety, perinatal pain and postpartum depression

Association of COMT gene polymorphism with perinatal anxiety, perinatal pain and postpartum depression

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500114449
Enrollment
Unknown
Registered
2025-12-11
Start date
2025-04-08
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Interventions

Grroup N2:Cesarean section
Group N1:Vaginal delivery

Sponsors

Wuxi people’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1.Age >= 18 years; 2.ASA I~III; 3.Women in labor;

Exclusion criteria

Exclusion criteria: 1.Severe cardiopulmonary function disease; 2.severe cerebrovascular disease; 3.severe liver and kidney function disease (Child-Pugh C, renal replacement therapy); 4.severe nervous system disease; 5.preoperative cognitive impairment (mini-mental state Examination score <= 23 points); 6.use of antipsychotic drugs; 7.alcohol abuse; 8.long-term opioid or other analgesic drugs; 9.inability to understand the postoperative recovery scale; 10.inability to understand the pain rating scale; 11.inability to provide informed consent;

Design outcomes

Primary

MeasureTime frame
Postpartum Depression Scores;catechol-O-methyltransferase genotype;Prenatal anxiety and depression scores;Pain scores at 24-48 hours postpartum;Stress indicators;

Secondary

MeasureTime frame
Complications of Pregnancy;General conditions of the mothers;Vital signs during labor;

Countries

China

Contacts

Public ContactQianYiling

Wuxi people’s Hospital

ylqian_1987@163.com+86 18915265254

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026