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The dosage requirements and influencing factors of sedative and analgesic drugs in adult patients during extracorporeal membrane oxygenation support

A retrospective study: Analysis of changes in sedative and analgesic drug dosages during extracorporeal membrane oxygenation support in adult patients

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500114435
Enrollment
Unknown
Registered
2025-12-11
Start date
2025-05-20
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Receiving ECMO support adult patients

Interventions

Patients with fentanyl in the non-ECMO group:None
Patients with fentanyl in the ECMO group:None
Patients with midazolam in the non-ECMO group:None
Patients with midazolam in ECMO group:None

Sponsors

Xiangya Hospital, Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years old upon admission to the ICU; 2. ECMO support for more than 24 hours; 3. Received sedative and analgesic medication treatment within 72 hours before ECMO; 4. Received sedative and analgesic medication treatment within 14 days after ECMO catheterization.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women; 2. Patients who had been intubated outside the hospital for more than 24 hours before transfer; 3. Patients who died within 48 hours after ECMO was initiated; 4. The missing rate of drug dose records in electronic medical records > 20% .

Design outcomes

Primary

MeasureTime frame
Length of hospital stay;Mortality status;Whether ECMO was successfully disbanded;Whether ECMO was passively disbanded;The reason for the withdrawal of ECMO;Therapeutic outcome;

Countries

China

Contacts

Public ContactDu Jie

Xiangya Hospital, Central South University

xiangyadujie@163.com+86 731 8975 3424

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026